RNH1

Across TCGA pan-cancer cohorts, RNH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RNH1 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNH1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNH1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where RNH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.877	0.706	.012	18	view →
UCEC	DFS	Tertile	II,III,IV	0.727	1.000	.032	10	view →
PDAC	OS	Tertile	All	0.597	0.454	.015	4	view →
CCRCC	DFS	Tertile	All	0.614	1.000	.021	2	view →
GBM	OS	Quartile	All	0.421	0.634	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RNH1–HNSC (DFS)

Open the HNSC breakdown →