RNH1

Across TCGA pan-cancer cohorts, RNH1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNH1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RNH1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNH1 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LIHC, and LUAD are the cancer types where RNH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−0.511	.001	10	view →
LIHC	Male	II,III,IV	+1.062	<.001	9	view →
LUAD	Male	II,III,IV	−0.832	<.001	9	view →
COAD	Female	All	+0.624	<.001	8	view →
UCEC	All	All	−0.862	<.001	6	view →
LUSC	Female	All	−0.602	<.001	6	view →
BRCA	All	II,III,IV	−0.262	.002	4	view →
CHOL	All	All	+1.383	<.001	3	view →
KIRP	Female	II,III,IV	+0.365	.020	2	view →
PRAD	All	All	−0.294	.008	2	view →
KICH	All	All	−0.416	.009	1	view →
KIRC	Female	All	+0.264	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNH1–BLCA

Open the BLCA breakdown →