RNH1

Across TCGA patient cohorts, RNH1 mutation is significantly associated with the RNA expression of many other genes, with 279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNH1-associated genes across cancer lineages are RNU2-38P, PRSS40B, and IL9RP1. Each is linked with RNH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNH1-to-partner and partner-to-RNH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-38P grouped by RNH1-low versus RNH1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNH1→partner) and Y-score (partner→RNH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU2-38P →	+0.540	+4.542	<.001	.001	3	2
SKCM	PRSS40B →	+0.405	+5.328	<.001	.003	3	2
SKCM	IL9RP1 →	+0.202	+4.241	<.001	.008	3	2
UCEC	RNU6-206P →	+0.209	+4.370	<.001	<.001	3	2
UCEC	RNA5SP424 →	+0.256	+2.920	<.001	.003	3	2
UCEC	PIEZO1P1 →	+0.100	+3.153	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 279 associations by consensus.

RNU2-38P by RNH1 expression — COAD

Explore this box plot interactively →