RNH1

Across TCGA patient cohorts, RNH1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNH1-associated genes across cancer lineages are PDK1_pS241, STAT3_pY705, and ATM. Each is linked with RNH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNH1-to-partner and partner-to-RNH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1_pS241 grouped by RNH1-low versus RNH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNH1→partner) and Y-score (partner→RNH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1_pS241 →	+0.226	+2.335	.008	.020	3	2
UCEC	STAT3_pY705 →	-0.348	-2.321	.008	.035	3	2
UCEC	ATM →	-0.487	-2.321	.032	.035	3	2
UCEC	EGFR_pY1068 →	-0.320	-3.459	.011	.005	3	1
UCEC	eIF4E →	+0.219	+3.321	.038	.010	3	1
UCEC	MEK1 →	+0.393	+3.321	.032	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PDK1_pS241 by RNH1 expression — UCEC

Explore this box plot interactively →