RNFT2

Across TCGA patient cohorts, RNFT2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNFT2-associated genes across cancer lineages are Notch1, Di-Ras3, and FOXO3a_pS318_S321. Each is linked with RNFT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNFT2-to-partner and partner-to-RNFT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by RNFT2-low versus RNFT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNFT2→partner) and Y-score (partner→RNFT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.234	+2.598	<.001	.005	3	2
UCEC	Di-Ras3 →	-0.147	-2.308	.016	.033	3	2
UCEC	FOXO3a_pS318_S321 →	-0.112	-2.000	.029	.029	3	1
UCEC	GATA3 →	-0.166	-2.301	.033	.034	3	1
UCEC	ACC1 →	+0.464	+2.335	.001	.018	3	1
UCEC	IGFBP2 →	-0.800	-1.874	.002	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Notch1 by RNFT2 expression — UCEC

Explore this box plot interactively →