RNF6

Across TCGA pan-cancer cohorts, RNF6 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNF6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNF6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RNF6 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LUAD, HNSC, and PDAC are the cancer types where RNF6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.451	<.001	6	view →
HNSC	All	III,IV	−0.347	.027	3	view →
PDAC	All	All	+0.821	.012	2	view →
CCRCC	All	All	+0.330	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RNF6–LUAD

Open the LUAD breakdown →