RNF43

Across TCGA cell cohorts, RNF43 mutation is significantly associated with the RNA expression of many other genes, with 1,858 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF43-associated genes across cancer lineages are DENND10, IER3IP1, and CDKN2AIP. Each is linked with RNF43 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF43-to-partner and partner-to-RNF43 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DENND10 grouped by RNF43-low versus RNF43-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF43→partner) and Y-score (partner→RNF43) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DENND10 →	+0.577	+2.584	<.001	.002	3	2
LARGE_INTESTINE	IER3IP1 →	+0.747	+3.130	<.001	<.001	3	2
LARGE_INTESTINE	CDKN2AIP →	+0.529	+2.700	<.001	.001	3	2
LARGE_INTESTINE	ARID2 →	+0.517	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	CS →	+0.384	+1.949	.009	.002	3	2
PANCREAS	PDXDC1 →	+0.722	+3.169	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,858 associations by consensus.

DENND10 by RNF43 expression — LARGE_INTESTINE

Explore this box plot interactively →