RNF41

Across TCGA pan-cancer cohorts, RNF41 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RNF41 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher RNF41 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RNF41 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where RNF41 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.623	1.000	.010	4	view →
LUAD	DFS	Tertile	III,IV	0.628	0.949	.023	3	view →
HNSC	OS	Tertile	III,IV	0.938	0.771	.043	2	view →
PDAC	DFS	Median	All	0.283	0.436	.040	2	view →
LSCC	DFS	Quartile	All	1.000	0.920	.037	2	view →
GBM	DFS	Quartile	All	0.822	0.610	.048	1	view →
CCRCC	DFS	Quartile	All	0.590	0.860	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RNF41–UCEC (OS)

Open the UCEC breakdown →