RNF4

Across TCGA patient cohorts, RNF4 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF4-associated genes across cancer lineages are eIF4G, FoxM1, and FOXO3a_pS318_S321. Each is linked with RNF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF4-to-partner and partner-to-RNF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by RNF4-low versus RNF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF4→partner) and Y-score (partner→RNF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.317	+3.169	.013	.018	3	1
UCEC	FoxM1 →	+0.239	+2.321	.025	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.142	-2.212	.005	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-1.874	.010	.049	3	1
UCEC	JNK2 →	+0.257	+3.026	.001	.018	3	1
UCEC	MEK1 →	+0.573	+4.087	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4G by RNF4 expression — UCEC

Explore this box plot interactively →