RNF4

Across TCGA cell cohorts, RNF4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,017 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF4-associated GO terms across cancer lineages are Positive regulation of CAMKK-AMPK signaling cascade, Organelle transport along microtubule, and Regulation of aggrephagy. Each is linked with RNF4 in more than 14 cancer types. Because this analysis shows association rather than direction, both RNF4-to-partner and partner-to-RNF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of CAMKK-AMPK signaling cascade grouped by RNF4-low versus RNF4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF4→partner) and Y-score (partner→RNF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of CAMKK-AMPK signaling cascade →	+0.758	+0.870	.009	.001	2	15
URINARY_TRACT	Organelle transport along microtubule →	+0.058	+0.738	.001	.006	3	14
LUNG_NSCLC_LUSC	Regulation of aggrephagy →	+0.170	+0.797	.001	.004	3	13
LIVER	Regulation of chromosome condensation →	+0.154	+0.683	<.001	<.001	3	13
BONE	Positive regulation of chromosome condensation →	+0.213	+0.651	.005	.005	3	13
LARGE_INTESTINE	Positive regulation of aggrephagy →	+0.189	+0.912	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

Positive regulation of CAMKK-AMPK signaling cascade by RNF4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →