RNF4

Across TCGA cell cohorts, RNF4 mutation is significantly associated with the mutation status of many other genes, with 696 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF4-associated genes across cancer lineages are CKAP5, MATR3, and HEATR5A. Each is linked with RNF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF4-to-partner and partner-to-RNF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKAP5 grouped by RNF4-low versus RNF4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF4→partner) and Y-score (partner→RNF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CKAP5 →	+3.541	+4.139	.003	.003	1	3
LUNG_NSCLC_LUAD	MATR3 →	+4.187	+5.000	.008	.008	1	3
LARGE_INTESTINE	HEATR5A →	+2.000	+2.662	.008	.008	1	3
LARGE_INTESTINE	PRKCI →	+2.678	+2.807	.006	.006	1	3
KIDNEY	PUS7 →	+4.786	+4.139	.001	.001	1	2
CNS	URB1 →	+3.693	+5.201	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 696 associations by consensus.

CKAP5 by RNF4 expression — CNS

Explore this box plot interactively →