RNF34

Across TCGA pan-cancer cohorts, RNF34 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF34 data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RNF34 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF34 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and CCRCC are the cancer types where RNF34 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	III,IV	0.875	0.287	<.001	29	view →
UCEC	OS	Tertile	All	1.000	0.848	.024	10	view →
CCRCC	DFS	Tertile	II,III,IV	0.230	1.000	.034	2	view →
PDAC	DFS	Median	II,III,IV	0.330	0.483	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF34–LUAD (DFS)

Open the LUAD breakdown →