RNF34

Across TCGA patient cohorts, RNF34 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF34-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and IGFBP2. Each is linked with RNF34 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF34-to-partner and partner-to-RNF34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RNF34-low versus RNF34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF34→partner) and Y-score (partner→RNF34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.720	+2.341	.005	.019	3	2
UCEC	EGFR_pY1068 →	-0.255	-2.115	.020	.019	3	1
UCEC	IGFBP2 →	-0.794	-2.115	.005	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.189	-2.321	.010	.034	3	1
UCEC	JNK2 →	+0.197	+2.115	.023	.019	3	1
UCEC	Ku80 →	+0.306	+2.820	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Caspase-7-cleavedD198 by RNF34 expression — UCEC

Explore this box plot interactively →