RNF34

Across TCGA cell cohorts, RNF34 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,904 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RNF34-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Cell cycle checkpoint signaling, and Transcription elongation-coupled chromatin remodeling. Each is linked with RNF34 in more than 15 cancer types. Because this analysis shows association rather than direction, both RNF34-to-partner and partner-to-RNF34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by RNF34-low versus RNF34-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF34→partner) and Y-score (partner→RNF34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.082	+1.050	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.100	+1.088	<.001	<.001	3	15
LUNG_SCLC	Transcription elongation-coupled chromatin remodeling →	+0.135	+0.612	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.079	+0.919	<.001	<.001	3	14
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.079	+0.478	.004	.003	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated DNA replication →	+0.130	+1.022	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,904 associations by consensus.

Negative regulation of cell cycle process by RNF34 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →