RNF31

Across TCGA pan-cancer cohorts, RNF31 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated RNF31 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RNF31 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RNF31 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where RNF31 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.152	0.669	<.001	40	view →
UCEC	DFS	Median	All	1.000	0.824	.002	36	view →
HNSC	DFS	Median	All	0.193	0.712	<.001	24	view →
OV	DFS	Median	II,III,IV	0.227	0.542	.015	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	12	view →
PRAD	DFS	Median	All	0.173	0.888	<.001	8	view →
BLCA	DFS	Median	All	1.000	0.331	.033	6	view →
LUSC	DFS	Median	II,III,IV	0.199	0.748	.006	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

RNF31–LUAD (OS)

Open the LUAD breakdown →