RNF31

Across TCGA patient cohorts, RNF31 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF31-associated genes across cancer lineages are TFRC, eIF4E, and Acetyl-a-Tubulin-Lys40. Each is linked with RNF31 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF31-to-partner and partner-to-RNF31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RNF31-low versus RNF31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF31→partner) and Y-score (partner→RNF31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.588	+1.584	<.001	.032	3	3
UCEC	eIF4E →	+0.176	+1.938	.011	.001	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.403	+1.512	.016	.017	3	2
UCEC	INPP4B →	-0.229	-2.906	.031	.001	3	2
UCEC	Ku80 →	+0.163	+1.405	.036	.012	3	2
UCEC	mTOR_pS2448 →	-0.139	-2.308	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TFRC by RNF31 expression — UCEC

Explore this box plot interactively →