RNF25

Across TCGA pan-cancer cohorts, RNF25 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RNF25 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher RNF25 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RNF25 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

GBM, LSCC, and LUAD are the cancer types where RNF25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.728	0.937	.012	14	view →
LSCC	OS	Median	All	0.800	0.929	.008	9	view →
LUAD	OS	Quartile	All	1.000	0.918	.019	8	view →
CCRCC	DFS	Quartile	II,III,IV	0.846	1.000	.032	4	view →
HNSC	OS	Median	III,IV	1.000	0.948	.043	2	view →
PDAC	OS	Median	All	0.387	0.579	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNF25–GBM (OS)

Open the GBM breakdown →