RNF25

Across TCGA pan-cancer cohorts, RNF25 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNF25’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNF25 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF25 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, HNSC, and LIHC are the cancer types where RNF25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.634	<.001	11	view →
HNSC	Male	III,IV	+0.738	<.001	10	view →
LIHC	All	III,IV	+1.005	<.001	9	view →
COAD	Female	II,III,IV	+0.791	<.001	7	view →
CHOL	Male	All	+1.813	<.001	5	view →
STAD	Male	II,III,IV	+0.620	<.001	5	view →
KIRC	Female	All	+0.414	.001	5	view →
READ	Male	All	+0.736	.005	4	view →
BRCA	All	III,IV	+0.280	.042	3	view →
ESCA	All	All	+0.624	.007	2	view →
UCEC	All	IV	−0.450	.030	2	view →
LUAD	All	III,IV	+0.267	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RNF25–KICH

Open the KICH breakdown →