RNF25

Across TCGA cell cohorts, RNF25 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,723 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF25-associated GO terms across cancer lineages are Protein-RNA covalent cross-linking repair, Protein deneddylation, and Spliceosomal tri-snRNP complex assembly. Each is linked with RNF25 in more than 19 cancer types. Because this analysis shows association rather than direction, both RNF25-to-partner and partner-to-RNF25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-RNA covalent cross-linking repair grouped by RNF25-low versus RNF25-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF25→partner) and Y-score (partner→RNF25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-RNA covalent cross-linking repair →	+0.144	+0.769	<.001	<.001	3	20
STOMACH	Protein deneddylation →	+0.116	+0.644	.003	.006	2	14
URINARY_TRACT	Spliceosomal tri-snRNP complex assembly →	+0.103	+0.766	.005	.003	3	12
PANCREAS	Positive regulation of mitotic cell cycle →	+0.079	+0.662	<.001	<.001	3	12
LIVER	Protein K6-linked ubiquitination →	+0.087	+0.488	.001	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Chromosome segregation →	+0.074	+0.500	.005	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,723 associations by consensus.

Protein-RNA covalent cross-linking repair by RNF25 expression — LUNG_SCLC

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