Across TCGA pan-cancer cohorts, RNF24 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNF24’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RNF24 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RNF24 is over-expressed in tumor.
LUAD are the cancer types where RNF24 tumor–normal differential expression is most reproducible.