RNF24

Across TCGA pan-cancer cohorts, RNF24 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RNF24 data layer compared with 6 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RNF24 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF24 expression acts as an unfavorable survival marker, although some lineages such as THYM and THCA show a favorable association.

KIRP, LIHC, and ACC are the cancer types where RNF24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.332	0.848	<.001	100	view →
LIHC	OS	Median	All	0.610	0.792	<.001	61	view →
ACC	DFS	Tertile	All	0.318	0.679	.002	38	view →
LUSC	OS	Tertile	II,III,IV	0.253	0.562	.008	33	view →
CESC	DFS	Median	All	0.778	0.863	.006	30	view →
SARC	OS	Median	All	0.412	0.769	<.001	30	view →
MESO	DFS	Tertile	All	0.281	0.769	.006	27	view →
KIRC	DFS	Quartile	II,III,IV	0.358	0.651	.001	24	view →
UVM	DFS	Median	All	0.344	0.662	.008	21	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
BLCA	DFS	Quartile	II,III,IV	0.273	0.447	.006	16	view →
THYM	DFS	Quartile	II,III,IV	0.946	0.492	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RNF24–KIRP (DFS)

Open the KIRP breakdown →