RNF227

Across TCGA patient cohorts, RNF227 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,377 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNF227-associated proteins across cancer lineages are YWHAE, PFAS, and METTL16. Each is linked with RNF227 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNF227-to-partner and partner-to-RNF227 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF227 versus YWHAE in BRCA, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF227→partner) and Y-score (partner→RNF227) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	YWHAE →	+0.313	+0.569	<.001	<.001	3	5
COAD	PFAS →	+0.384	+0.509	.001	<.001	3	5
OV	METTL16 →	+0.265	+0.706	<.001	<.001	3	5
GBM	PTPRC_S994 →	-0.683	-0.307	<.001	.001	3	4
LSCC	RASAL3_S51 →	-0.391	-0.522	<.001	<.001	3	4
HNSC	WARS1 →	-0.626	-0.449	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,377 associations by consensus.

RNF227 vs YWHAE — BRCA

Explore this scatter interactively →