RNF227

Across TCGA pan-cancer cohorts, RNF227 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RNF227 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher RNF227 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF227 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

UCS, KICH, and BRCA are the cancer types where RNF227 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Median	IV	0.952	0.367	.001	80	view →
KICH	OS	Median	All	0.669	1.000	.002	57	view →
BRCA	OS	Median	IV	0.866	0.339	<.001	53	view →
CESC	DFS	Tertile	All	0.846	0.665	.001	46	view →
LIHC	OS	Tertile	All	0.406	0.591	.001	43	view →
LGG	OS	Median	All	0.369	0.516	<.001	37	view →
KIRC	DFS	Tertile	All	0.855	0.666	.008	35	view →
UCEC	DFS	Tertile	II,III,IV	0.888	0.770	.005	28	view →
ACC	DFS	Tertile	All	0.238	0.589	.008	18	view →
COAD	DFS	Tertile	All	0.387	0.772	.008	16	view →
HNSC	DFS	Quartile	All	0.736	0.578	.009	14	view →
LUSC	OS	Median	II,III,IV	0.801	0.650	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RNF227–UCS (DFS)

Open the UCS breakdown →