RNF225

Across TCGA cell cohorts, RNF225 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,929 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RNF225-associated GO terms across cancer lineages are Regulation of type I interferon-mediated signaling pathway, Endosomal transport, and Regulation of ruffle assembly. Each is linked with RNF225 in more than 8 cancer types. Because this analysis shows association rather than direction, both RNF225-to-partner and partner-to-RNF225 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of type I interferon-mediated signaling pathway grouped by RNF225-low versus RNF225-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF225→partner) and Y-score (partner→RNF225) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of type I interferon-mediated signaling pathway →	+0.069	+0.057	<.001	.004	3	9
STOMACH	Endosomal transport →	+0.040	+0.077	.009	.009	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of ruffle assembly →	+0.131	+0.331	<.001	<.001	3	8
CNS	Negative regulation of autophagosome maturation →	+0.086	+0.020	<.001	<.001	3	8
BLOOD_Lymphoma	Negative regulation of mRNA splicing, via spliceosome →	+0.061	+0.048	<.001	.002	3	8
STOMACH	Vacuolar transport →	+0.048	+0.079	.005	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,929 associations by consensus.

Regulation of type I interferon-mediated signaling pathway by RNF225 expression — STOMACH

Explore this box plot interactively →