RNF225

Across TCGA pan-cancer cohorts, RNF225 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RNF225 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RNF225 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF225 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

SKCM, COAD, and MESO are the cancer types where RNF225 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.677	0.825	<.001	96	view →
COAD	OS	Median	All	0.462	0.697	<.001	86	view →
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
HNSC	OS	Tertile	IV	0.492	0.269	.007	51	view →
LIHC	DFS	Tertile	II,III,IV	0.189	0.356	.003	51	view →
GBM	DFS	Tertile	All	0.275	0.170	.005	33	view →
SCLC	DFS	Tertile	All	0.774	0.498	.001	26	view →
OV	OS	Quartile	III,IV	0.241	0.373	.003	20	view →
STAD	OS	Tertile	II,III,IV	0.381	0.699	.011	18	view →
UVM	DFS	Tertile	All	0.435	0.792	.005	18	view →
ACC	DFS	Tertile	All	0.409	0.769	.003	18	view →
PAAD	DFS	Quartile	All	0.249	0.401	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

RNF225–SKCM (OS)

Open the SKCM breakdown →