RNF224

Across TCGA patient cohorts, RNF224 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF224-associated genes across cancer lineages are MIR412, TRAPPC2P8, and MIR4476. Each is linked with RNF224 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF224-to-partner and partner-to-RNF224 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR412 grouped by RNF224-low versus RNF224-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF224→partner) and Y-score (partner→RNF224) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR412 →	+0.621	+8.066	<.001	.007	3	1
UCEC	TRAPPC2P8 →	+0.109	+8.066	<.001	.007	3	1
UCEC	MIR4476 →	+0.736	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MIR412 by RNF224 expression — UCEC

Explore this box plot interactively →