RNF224

Across TCGA pan-cancer cohorts, RNF224 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated RNF224 data layer compared with 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNF224 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF224 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UVM show a favorable association.

COAD, HNSC, and ACC are the cancer types where RNF224 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.781	0.911	<.001	97	view →
HNSC	OS	Tertile	All	0.561	0.278	.001	91	view →
ACC	DFS	Median	All	0.382	0.762	<.001	84	view →
KIRP	DFS	Tertile	All	0.689	0.960	.003	52	view →
UVM	OS	Tertile	All	0.810	0.485	.004	26	view →
ESCA	OS	Quartile	III,IV	0.791	0.310	<.001	24	view →
LGG	DFS	Tertile	All	0.653	0.805	<.001	21	view →
PRAD	DFS	Median	All	0.690	0.878	<.001	20	view →
SKCM	DFS	Median	IV	0.660	0.155	.031	12	view →
THCA	DFS	Median	III,IV	0.766	0.931	.007	11	view →
MESO	OS	Quartile	IV	0.178	0.821	.020	9	view →
PAAD	OS	Median	All	0.659	0.349	.010	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

RNF224–COAD (OS)

Open the COAD breakdown →