RNF217

Across TCGA patient cohorts, RNF217 protein abundance is significantly associated with the RNA expression of many other genes, with 252 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNF217-associated genes across cancer lineages are POLE2, ARFGAP1, and RAB40AL. Each is linked with RNF217 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF217-to-partner and partner-to-RNF217 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF217 versus POLE2 in LSCC, with a Pearson correlation of -0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF217→partner) and Y-score (partner→RNF217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLE2 →	-0.993	-0.804	.005	.006	3	1
LSCC	ARFGAP1 →	-0.407	-0.824	.002	.006	3	1
LSCC	RAB40AL →	-0.487	-0.860	.001	.001	3	1
LSCC	ACD →	-0.844	-0.863	.003	.004	3	1
LSCC	LHB →	-1.202	-0.731	.001	<.001	3	1
LSCC	MED25 →	-1.059	-0.714	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 252 associations by consensus.

RNF217 vs POLE2 — LSCC

Explore this scatter interactively →