RNF217

Across TCGA pan-cancer cohorts, RNF217 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RNF217 data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RNF217 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF217 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

BLCA, LUAD, and STAD are the cancer types where RNF217 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.549	0.683	<.001	94	view →
LUAD	OS	Median	All	0.610	0.749	<.001	80	view →
STAD	DFS	Median	All	0.481	0.619	.002	61	view →
MESO	OS	Quartile	All	0.246	0.497	.004	32	view →
ACC	DFS	Quartile	All	0.373	0.702	.004	31	view →
UCS	DFS	Median	II,III,IV	0.549	0.139	.001	30	view →
KICH	DFS	Median	III,IV	0.289	0.901	.002	30	view →
SKCM	OS	Tertile	IV	0.833	0.382	.002	28	view →
HNSC	OS	Quartile	II,III,IV	0.670	0.912	.009	19	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	19	view →
LAML	DFS	Tertile	All	0.273	0.623	.009	18	view →
ESCA	OS	Tertile	All	1.000	0.489	.011	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RNF217–BLCA (DFS)

Open the BLCA breakdown →