RNF217

Across TCGA patient cohorts, RNF217 mutation is significantly associated with the RNA expression of many other genes, with 2,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF217-associated genes across cancer lineages are ANKRD26P2, GLA, and ENO2. Each is linked with RNF217 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF217-to-partner and partner-to-RNF217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD26P2 grouped by RNF217-low versus RNF217-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF217→partner) and Y-score (partner→RNF217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ANKRD26P2 →	+0.084	+5.418	<.001	.005	3	2
SKCM	GLA →	+0.442	+2.826	.008	.001	3	2
SKCM	ENO2 →	+1.173	+3.472	.002	.002	3	2
UCEC	ELK1 →	+0.458	+2.343	.004	.003	3	2
SKCM	ABHD8 →	+0.613	+3.237	.001	.009	3	2
SKCM	PIN1 →	+0.417	+3.510	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,220 associations by consensus.

ANKRD26P2 by RNF217 expression — CESC

Explore this box plot interactively →