RNF217

Across TCGA patient cohorts, RNF217 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF217-associated genes across cancer lineages are JNK_pT183_Y185, 14-3-3_beta, and A-Raf_pS299. Each is linked with RNF217 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF217-to-partner and partner-to-RNF217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RNF217-low versus RNF217-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF217→partner) and Y-score (partner→RNF217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.216	-2.571	.005	.011	3	2
UCEC	14-3-3_beta →	-0.123	-2.571	.008	.011	2	2
UCEC	A-Raf_pS299 →	-0.166	-3.321	.002	.010	3	1
UCEC	GATA6 →	-0.162	-2.577	.024	.011	3	1
UCEC	MEK1 →	+0.365	+2.321	.032	.034	3	1
UCEC	Notch1 →	+0.138	+3.013	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

JNK_pT183_Y185 by RNF217 expression — UCEC

Explore this box plot interactively →