RNF217

Across TCGA cell cohorts, RNF217 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,430 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible RNF217-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Cytoplasmic translation. Each is linked with RNF217 in more than 14 cancer types. Because this analysis shows association rather than direction, both RNF217-to-partner and partner-to-RNF217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by RNF217-low versus RNF217-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF217→partner) and Y-score (partner→RNF217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.103	+1.553	<.001	<.001	3	15
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.102	+1.605	.004	<.001	3	14
OESOPHAGUS	Cytoplasmic translation →	+0.079	+1.593	.003	<.001	3	13
LARGE_INTESTINE	Regulation of translational initiation →	+0.071	+1.217	<.001	.008	3	13
LIVER	Regulation of organelle assembly →	+0.041	+1.643	<.001	<.001	3	13
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.089	+1.223	.003	.007	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,430 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by RNF217 expression — BREAST

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