RNF217

Across TCGA cell cohorts, RNF217 mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF217-associated genes across cancer lineages are TXN2, CCDC34, and P3H3. Each is linked with RNF217 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF217-to-partner and partner-to-RNF217 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXN2 grouped by RNF217-low versus RNF217-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF217→partner) and Y-score (partner→RNF217) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXN2 →	+0.570	+3.067	.002	.009	3	1
LARGE_INTESTINE	CCDC34 →	+0.668	+3.212	<.001	.006	3	1
LARGE_INTESTINE	P3H3 →	+1.778	+3.082	.001	.007	3	1
LARGE_INTESTINE	NDUFA2 →	+0.403	+3.067	.005	.009	3	1
LARGE_INTESTINE	CDCA8 →	+0.573	+3.212	.004	.006	3	1
LARGE_INTESTINE	FAU →	+0.458	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

TXN2 by RNF217 expression — LARGE_INTESTINE

Explore this box plot interactively →