RNF216

Across TCGA cell cohorts, RNF216 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible RNF216-associated genes across cancer lineages are SHCBP1L, GJA8, and MOGAT1. Each is linked with RNF216 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF216-to-partner and partner-to-RNF216 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1L grouped by RNF216-low versus RNF216-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF216→partner) and Y-score (partner→RNF216) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SHCBP1L →	+0.042	+4.087	.001	.009	3	2
URINARY_TRACT	GJA8 →	+0.015	+4.087	<.001	.009	3	1
URINARY_TRACT	MOGAT1 →	+0.039	+4.217	<.001	.005	3	1
URINARY_TRACT	LECT2 →	+0.848	+4.217	<.001	.005	3	1
URINARY_TRACT	OR51I1 →	+0.139	+4.217	<.001	.005	3	1
URINARY_TRACT	OR1A1 →	+0.005	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

SHCBP1L by RNF216 expression — URINARY_TRACT

Explore this box plot interactively →