RNF216-IT1

Across TCGA pan-cancer cohorts, RNF216-IT1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RNF216-IT1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RNF216-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF216-IT1 expression acts as an unfavorable survival marker, although some lineages such as SARC and LAML show a favorable association.

LIHC, KIRC, and UVM are the cancer types where RNF216-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.275	0.483	<.001	69	view →
KIRC	DFS	Median	All	0.484	0.742	<.001	61	view →
UVM	DFS	Tertile	II,III,IV	0.292	0.527	.010	54	view →
CESC	OS	Tertile	All	0.805	0.898	.006	30	view →
THCA	OS	Quartile	III,IV	0.945	1.000	.009	25	view →
KIRP	OS	Quartile	II,III,IV	0.237	0.787	.001	23	view →
OV	OS	Quartile	All	0.810	0.913	.004	18	view →
SARC	OS	Quartile	All	0.657	0.418	.011	13	view →
READ	OS	Median	III,IV	0.434	0.944	.006	13	view →
LAML	DFS	Quartile	All	0.643	0.297	.011	12	view →
LUSC	OS	Tertile	II,III,IV	1.000	0.736	.003	12	view →
LGG	DFS	Quartile	All	0.716	0.873	.001	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RNF216-IT1–LIHC (DFS)

Open the LIHC breakdown →