RNF216-IT1

Across TCGA pan-cancer cohorts, RNF216-IT1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RNF216-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RNF216-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF216-IT1 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

BLCA, HNSC, and UCEC are the cancer types where RNF216-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF216-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−0.937	.002	8	view →
HNSC	Male	All	+0.153	.002	8	view →
UCEC	All	II,III,IV	−0.511	.015	6	view →
COAD	All	All	−0.242	.001	5	view →
BRCA	All	IV	−0.865	.005	4	view →
KIRC	All	All	+0.100	.002	4	view →
READ	Female	All	−0.642	.026	2	view →
LUSC	All	All	−0.187	.003	2	view →
CHOL	All	All	+0.165	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RNF216-IT1–BLCA

Open the BLCA breakdown →