RNF215

Across TCGA patient cohorts, RNF215 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF215-associated genes across cancer lineages are IGFBP2, PKC-a_pS657, and PKC-a. Each is linked with RNF215 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF215-to-partner and partner-to-RNF215 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by RNF215-low versus RNF215-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF215→partner) and Y-score (partner→RNF215) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.878	-2.321	.007	.035	3	1
UCEC	PKC-a_pS657 →	+0.449	+3.009	.019	.019	3	1
UCEC	PKC-a →	+0.496	+2.321	.014	.035	3	1
UCEC	AMPK_pT172 →	+0.472	+3.000	.022	.036	3	1
UCEC	Rad50 →	-0.266	-3.459	.029	.005	3	1
UCEC	p62 Lck ligand →	+0.545	+3.459	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

IGFBP2 by RNF215 expression — UCEC

Explore this box plot interactively →