RNF214

Across TCGA pan-cancer cohorts, RNF214 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RNF214 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNF214 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RNF214 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD and PDAC are the cancer types where RNF214 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

RNF214–COAD (DFS)

Open the COAD breakdown →