RNF214

Across TCGA patient cohorts, RNF214 mutation is significantly associated with the RNA expression of many other genes, with 1,004 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF214-associated genes across cancer lineages are MBD3L3, RNU4-73P, and TRIM51GP. Each is linked with RNF214 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF214-to-partner and partner-to-RNF214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by RNF214-low versus RNF214-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF214→partner) and Y-score (partner→RNF214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MBD3L3 →	+0.565	+6.144	<.001	.001	3	2
CESC	RNU4-73P →	+0.472	+5.812	<.001	.003	3	2
CESC	TRIM51GP →	+0.714	+5.201	<.001	.007	3	2
SKCM	RN7SL813P →	+0.067	+3.748	<.001	.002	3	2
BRCA	LINC02546 →	+0.042	+5.866	.001	.001	3	2
READ	MIR541 →	+0.381	+5.257	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,004 associations by consensus.

MBD3L3 by RNF214 expression — CESC

Explore this box plot interactively →