RNF214

Across TCGA patient cohorts, RNF214 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF214-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Notch1. Each is linked with RNF214 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF214-to-partner and partner-to-RNF214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RNF214-low versus RNF214-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF214→partner) and Y-score (partner→RNF214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.218	-2.700	.013	.006	3	2
UCEC	ERK2 →	+0.148	+1.874	.029	.049	3	2
UCEC	Notch1 →	+0.197	+2.331	<.001	.003	3	2
UCEC	p62 Lck ligand →	+0.464	+2.874	<.001	<.001	3	2
UCEC	STAT5a →	+0.407	+2.392	.003	<.001	3	2
UCEC	Cyclin-E1 →	+0.352	+2.584	.022	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by RNF214 expression — UCEC

Explore this box plot interactively →