RNF214

Across TCGA cell cohorts, RNF214 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RNF214-associated genes across cancer lineages are OR2M5, OR51I1, and PPDPFL. Each is linked with RNF214 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF214-to-partner and partner-to-RNF214 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by RNF214-low versus RNF214-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF214→partner) and Y-score (partner→RNF214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2M5 →	+0.014	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR51I1 →	+0.486	+4.369	<.001	.008	3	1
SOFT_TISSUE	PPDPFL →	+0.078	+4.222	<.001	.007	3	1
SOFT_TISSUE	OR6C2 →	+0.014	+4.369	.001	.008	3	1
SOFT_TISSUE	MRGPRX4 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	PTCHD3 →	+1.226	+4.635	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR2M5 by RNF214 expression — SOFT_TISSUE

Explore this box plot interactively →