RNF213

Across TCGA cell cohorts, RNF213 mutation is significantly associated with the RNA expression of many other genes, with 2,885 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF213-associated genes across cancer lineages are WRAP53, CNTROB, and TOP3A. Each is linked with RNF213 in more than 3 cancer types. Because this analysis shows association rather than direction, both RNF213-to-partner and partner-to-RNF213 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WRAP53 grouped by RNF213-low versus RNF213-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF213→partner) and Y-score (partner→RNF213) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WRAP53 →	+0.557	+1.850	<.001	<.001	3	4
LARGE_INTESTINE	CNTROB →	+0.734	+2.180	<.001	<.001	3	4
LARGE_INTESTINE	TOP3A →	+0.552	+1.557	.001	.001	3	4
LARGE_INTESTINE	CDCA2 →	+0.678	+2.008	<.001	<.001	3	4
URINARY_TRACT	USP45 →	+0.600	+3.000	.005	.009	3	3
LARGE_INTESTINE	SGSM3 →	+0.821	+2.180	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,885 associations by consensus.

WRAP53 by RNF213 expression — LARGE_INTESTINE

Explore this box plot interactively →