RNF213-AS1

Across TCGA pan-cancer cohorts, RNF213-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RNF213-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RNF213-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF213-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

COAD, BRCA, and BLCA are the cancer types where RNF213-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.526	0.837	<.001	84	view →
BRCA	OS	Tertile	III,IV	0.693	0.411	<.001	83	view →
BLCA	OS	Tertile	All	0.823	0.649	.001	46	view →
ACC	DFS	Tertile	All	0.234	0.647	<.001	35	view →
CHOL	DFS	Median	All	0.180	0.641	.004	28	view →
HNSC	DFS	Tertile	IV	0.448	0.230	.001	27	view →
UCEC	DFS	Tertile	All	0.926	0.850	.007	24	view →
KICH	OS	Median	III,IV	0.759	1.000	.004	19	view →
LGG	DFS	Median	All	0.297	0.467	.004	15	view →
ESCA	OS	Median	IV	0.222	0.698	.006	12	view →
UVM	DFS	Median	All	0.712	0.505	.025	9	view →
MESO	DFS	Median	IV	0.201	0.426	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RNF213-AS1–COAD (OS)

Open the COAD breakdown →