RNF213-AS1

Across TCGA pan-cancer cohorts, RNF213-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNF213-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNF213-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF213-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where RNF213-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF213-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.894	<.001	9	view →
KICH	Male	All	−0.967	<.001	7	view →
LUSC	All	II,III,IV	−0.507	<.001	6	view →
BRCA	Female	All	−0.324	<.001	6	view →
LIHC	Female	All	+0.150	<.001	6	view →
CHOL	All	All	+1.195	<.001	5	view →
LUAD	Female	II,III,IV	−0.514	.001	5	view →
COAD	Female	II,III,IV	+0.212	.001	5	view →
UCEC	All	All	−0.436	.010	2	view →
KIRP	All	All	−0.430	.001	2	view →
KIRC	Female	All	+0.325	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNF213-AS1–THCA

Open the THCA breakdown →