Across TCGA cell cohorts, RNF208 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF208-associated genes across cancer lineages are EPPIN, ACTRT1, and OR52E4. Each is linked with RNF208 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF208-to-partner and partner-to-RNF208 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF208→partner) and Y-score (partner→RNF208) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	ACTRT1 →	+0.021	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	OR6C70 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

RNF208 survival (RNA) · tumor vs normal (RNA) · all RNF208 data types