RNF207

Across TCGA patient cohorts, RNF207 mutation is significantly associated with the RNA expression of many other genes, with 1,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF207-associated genes across cancer lineages are RNU6-246P, RN7SL134P, and RN7SL199P. Each is linked with RNF207 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF207-to-partner and partner-to-RNF207 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-246P grouped by RNF207-low versus RNF207-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF207→partner) and Y-score (partner→RNF207) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-246P →	+1.197	+4.341	<.001	.009	3	2
CESC	RN7SL134P →	+0.153	+4.874	<.001	.002	3	2
CESC	RN7SL199P →	+0.107	+4.969	<.001	.004	3	2
UCEC	RBM15 →	+0.357	+2.716	.003	.003	3	2
SKCM	RNU6-1127P →	+0.378	+5.867	<.001	.003	3	2
UCEC	MRPL18 →	+0.410	+2.711	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,158 associations by consensus.

RNU6-246P by RNF207 expression — BRCA

Explore this box plot interactively →