RNF207

Across TCGA patient cohorts, RNF207 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF207-associated genes across cancer lineages are TFRC, 4E-BP1_pT37_T46, and EGFR_pY1068. Each is linked with RNF207 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF207-to-partner and partner-to-RNF207 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by RNF207-low versus RNF207-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF207→partner) and Y-score (partner→RNF207) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.482	+2.584	.020	.010	3	2
UCEC	4E-BP1_pT37_T46 →	-0.336	-2.308	.022	.033	3	2
UCEC	EGFR_pY1068 →	-0.203	-2.000	.039	.010	3	1
UCEC	eIF4E →	+0.185	+3.183	.025	.009	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.105	.018	.017	3	1
UCEC	INPP4B →	-0.281	-3.321	.027	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TFRC by RNF207 expression — UCEC

Explore this box plot interactively →