RNF2

Across TCGA patient cohorts, RNF2 mutation is significantly associated with the RNA expression of many other genes, with 2,526 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF2-associated genes across cancer lineages are MIR489, LINC01040, and RNA5SP146. Each is linked with RNF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF2-to-partner and partner-to-RNF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR489 grouped by RNF2-low versus RNF2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF2→partner) and Y-score (partner→RNF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR489 →	+0.420	+7.924	<.001	.008	3	2
LUAD	LINC01040 →	+1.288	+5.343	<.001	.006	3	2
UCEC	RNA5SP146 →	+0.291	+2.022	<.001	.006	3	2
UCEC	RN7SL592P →	+0.122	+1.901	.006	.002	3	2
SKCM	MIR3666 →	+0.394	+5.098	<.001	<.001	3	2
BRCA	MIR6515 →	+0.432	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,526 associations by consensus.

MIR489 by RNF2 expression — LUSC

Explore this box plot interactively →