RNF2

Across TCGA cell cohorts, RNF2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF2-associated genes across cancer lineages are DPEP2, OR10W1, and TAFA1. Each is linked with RNF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF2-to-partner and partner-to-RNF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPEP2 grouped by RNF2-low versus RNF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF2→partner) and Y-score (partner→RNF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DPEP2 →	+0.144	+3.355	.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	C14orf180 →	+0.155	+3.477	<.001	.001	3	1
LARGE_INTESTINE	NAT8B →	+0.678	+3.667	.005	.003	3	1
LARGE_INTESTINE	LRRC3C →	+0.296	+3.921	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

DPEP2 by RNF2 expression — LARGE_INTESTINE

Explore this box plot interactively →