RNF19A

Across TCGA patient cohorts, RNF19A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF19A-associated genes across cancer lineages are EGFR_pY1068, ERK2, and INPP4B. Each is linked with RNF19A in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF19A-to-partner and partner-to-RNF19A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RNF19A-low versus RNF19A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF19A→partner) and Y-score (partner→RNF19A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.373	-2.874	<.001	<.001	3	2
UCEC	ERK2 →	+0.161	+1.362	.017	.037	3	2
UCEC	INPP4B →	-0.255	-2.000	.025	.029	3	2
UCEC	MAPK_pT202_Y204 →	-0.390	-2.222	.018	.010	3	2
UCEC	MEK1 →	+0.307	+1.906	.017	.015	3	2
UCEC	Shc_pY317 →	-0.263	-3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by RNF19A expression — UCEC

Explore this box plot interactively →